2. Signaling Pathways
  3. Vitamin D Related/Nuclear Receptor
  4. Thyroid Hormone Receptor

Thyroid Hormone Receptor

THR

Thyroid Hormone Receptor

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Thyroid hormone receptor is a member of the nuclear receptor superfamily that shuttles between the cytosol and nucleus. Thyroid hormone receptors are ligand-dependent transcription factors that mediate the biological activities of thyroid hormone (T3). Thyroid hormone receptors are encoded by two genes, one for TRα and another for TRβ, which encode the major isoforms of TR, including TRα1, TRα2, TRβ1, and TRβ2. The thyroid hormone receptors mediate the pleiotropic activities of the thyroid hormone (T3) in growth, development, and differentiation and in maintaining metabolic homeostasis.

Thyroid hormone receptors are zinc finger transcription factors in the erbA superfamily that bind DNA at specific response element sequences (thyroid hormone response elements, TREs) and activate gene expression in response to thyroid hormone (T3). Thyroid hormone receptors have been shown to bind DNA as monomers, homodimers, or heterodimers with another erbA superfamily member, the retinoid X receptor (RXR).

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-111288
    MB-07811
    		Agonist 99.09%
    MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB07344, a liver-targeted thyroid hormone receptor-β agonist. MB-07811 has cholesterol and triglycerides lowering activity.
    MB-07811
  • HY-W011927S
    4,4'-Sulfonyldiphenol-d8
    		Agonist 98.88%
    4,4'-Sulfonyldiphenol-d8 (Bisphenol S (4,4'-Sulfonyldiphenol)-d8) is the deuterium labeled 4,4'-Sulfonyldiphenol (HY-W011927).4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone), a substitute for Bisphenol A (HY-18260), is widely used in industrial and consumer products. 4,4'-Sulfonyldiphenol is an estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR) with IC50 values for TRα and TRβ are 2650 μM and 2294 μM respectively, thereby affecting breast development and reducing the expression of androgen receptor (AR) in fetal testes. 4,4'-Sulfonyldiphenol promotes the progression of glioblastoma by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway. Under chronic exposure, 4,4'-Sulfonyldiphenol can cause significant lipid deposition and dyslipidemia in the mouse liver by upregulating JunB and Atf3, and has a role in causing obesity at low doses. 4,4'-Sulfonyldiphenol induces intestinal inflammation by altering the intestinal microbiome. 4,4'-Sulfonyldiphenol accelerates the progression of atherosclerosis in zebrafish embryo larvae.
    4,4'-Sulfonyldiphenol-d<sub>8</sub>
  • HY-P10078
    pTH (39-84) (human)
    		98.88%
    pTH (39-84) (human) is a parathyroid hormone (PTH) C-terminal fragment. pTH (39-84) (human) stimulates osteoclast formation.
    pTH (39-84) (human)
  • HY-P4697A
    pTH (44-68) (human) TFA
    		98.09%
    pTH (44-68) (human) TFA is a fragment of human parathyroid hormone (pTH) that lacks the adenylate cyclase-stimulating activity of intact pTH. pTH (44-68) (human) TFA can be used to study the mechanism of action of pTH.
    pTH (44-68) (human) TFA
  • HY-106608
    Glutaurine
    Glutaurine containing glutamine and taurine residues is an orally active hormone of the parathyroid. Glutaurine, as a hormone, is isolated from parathyroid gland oxyphil cells. Glutaurine can be used for the research of antiepileptic and anti-amnesia.
    Glutaurine
  • HY-114806
    Fenclofenac
    		99.09%
    Fenclofenac is an orally active anti-inflammatory agent with a low ulcerogenic effect. Fenclofenac also exhibits antipyretic and analgesic activities, with an oral LD50 of 2280 mg/kg in rats. Fenclofenac can be utilized in inflammation research.
    Fenclofenac
  • HY-P3960
    (Glu2)-TRH
    		Inhibitor 99.96%
    (Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH; HY-P0002), is a negative modulator for the cholinergic effect of TRH in the mouse brain. (Glu2)-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2)-TRH is not metabolized by thyroliberinase. (Glu2)-TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS.
    (Glu2)-TRH
  • HY-P2279A
    Parathyroid hormone (1-34) (rat) acetate
    		Antagonist 99.87%
    Parathyroid hormone (1-34) (rat) (acetate) is a parathyroid hormone. Parathyroid hormone (1-34) (rat) improves both cortical and cancellous bone structure. Parathyroid hormone (1-34) (rat) can be used for the research of osteoporosis.
    Parathyroid hormone (1-34) (rat) acetate
  • HY-A0070R
    Liothyronine sodium (Standard)
    		Activator
    Liothyronine (sodium) (Standard) is the analytical standard of Liothyronine (sodium). This product is intended for research and analytical applications. Liothyronine sodium is an active form of thyroid hormone. Liothyronine sodium is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively.
    Liothyronine sodium (Standard)
  • HY-156679
    VK-0214
    		Antagonist 99.87%
    VK-0214 is an agonist of the thyroid β receptor (TRβ). By activating the expression of ABCD2, it can reduce the accumulation of very long-chain fatty acids (VLCFAs) and further alleviate glioblastoma multiforme. VK-0214 has the effect of regulating fatty acid metabolism and can be used in the research of X-linked adrenoleukodystrophy (X-ALD).
    VK-0214
  • HY-12753A
    Debutyldronedarone hydrochloride
    		Inhibitor 98.32%
    Debutyldronedarone (SR35021) hydrochloride, the main metabolite of Dronedarone, is a selective thyroid hormone receptor α1 (TRα1) inhibitor. Debutyldronedarone hydrochloride inhibits T3 binding to TRα1 and TRβ1 by 77% and 25%, respectively. Debutyldronedarone hydrochloride can be used for the research of arrhythmic.
    Debutyldronedarone hydrochloride
  • HY-130012
    CO23
    		Agonist 98.00%
    CO23 is a selective thyroid hormone receptor (TR) α agonist and used for growth and development regulation. CO23 was able to be transported through the blood-brain barrier.
    CO23
  • HY-114272A
    T4-ATA (S-isomer)
    		99.50%
    T4-ATA S-isomer is the S-isomer of T4-ATA, which is the active form of the thyroid hormone.
    T4-ATA (S-isomer)
  • HY-163945
    ZTA-261
    		Agonist 99.94%
    ZTA-261 is a highly selective and low toxic thyroid hormone receptor β subtype (THR-β) agonist (IC50=6.3 nM) that reduces body weight and visceral fat through a liothyronine (HY-A0070A) mediated pathway. ZTA-261 can be used in the study of lipid metabolism and obesity prevalence.
    ZTA-261
  • HY-P1252
    Parathyroid Hormone (1-34), bovine
    		Agonist 99.88%
    Parathyroid Hormone (1-34), bovine is a potent parathyroid hormone (PTH) receptor agonist. Parathyroid Hormone (1-34), bovine increases calcium and inorganic phosphate levels in vivo. Parathyroid Hormone (1-34), bovine can be used for th reseach of osteoporosis.
    Parathyroid Hormone (1-34), bovine
  • HY-158269
    T4-BSA
    T4-BSA is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    T4-BSA
  • HY-A0070AG
    Liothyronine (GMP)
    		Agonist
    Liothyronine (Triiodothyronine) (GMP) is the Liothyronine (HY-A0070A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively.
    Liothyronine (GMP)
  • HY-14401
    Encaleret
    		99.88%
    Encaleret (CLTX-305) is an orally active antagonist of the calcium-sensing receptor (CaSR), with an IC50 of 0.012 μM. Encaleret can promote the secretion of parathyroid hormone. Encaleret can be used in the research of diseases such as osteoporosis and autosomal dominant hypocalcemia type 1.
    Encaleret
  • HY-106425
    Omzotirome
    		99.89%
    Omzotirome (TRC150094), a functional analog of iodothyronines, can be used for the research of hyperlipidaemia (WO2008149379).
    Omzotirome
  • HY-B0208S
    Methimazole-d3
    		Inhibitor 99.72%
    Methimazole-d3 is a deuterium labeled Methimazole (HY-B0208). Methimazole (Thiamazole) is an anti-thyroid agent, which blocks thyroid hormone production from the thyroid gland. Metamizol can cause hepatotoxicity.
    Methimazole-d<sub>3</sub>
Cat. No. Product Name / Synonyms Application Reactivity